Electrical stimulation systems for cardiac tissue engineering
نویسندگان
چکیده
منابع مشابه
Biomimetic Electrical Stimulation for Cardiac Tissue Engineering
A major challenge of tissue engineering is directing cells to establish the physiological structure and function of the tissue being replaced. Electrical stimulation has been used to induce synchronous contractions of cultured cardiac constructs. The hypothesis adopted for this study is that functional cardiac constructs can be engineered by "mimicking" the conditions present during cardiac dev...
متن کاملOptimization of electrical stimulation parameters for cardiac tissue engineering.
In vitro application of pulsatile electrical stimulation to neonatal rat cardiomyocytes cultured on polymer scaffolds has been shown to improve the functional assembly of cells into contractile engineered cardiac tissues. However, to date, the conditions of electrical stimulation have not been optimized. We have systematically varied the electrode material, amplitude and frequency of stimulatio...
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Introduction: The direct approach of cardiac tissue engineering is to mimic the natural tissue of heart, considering the significant role of scaffolding and mechanical simulation. Methods: To achieve this purpose, a composite Polycaprolactone (PCL)/Gelatin electrospun scaffold with a ratio of 70:30 and with the most similarities to the cardiac extracellular matrix was fabricated with aligned ...
متن کاملHydrogels for Cardiac Tissue Engineering
Cardiac tissue regeneration is an integrated process involving both cells and supporting matrix. Cardiomyocytes and stem cells are utilized to regenerate cardiac tissue. Hydrogels, because of their tissue-like properties, have been used as supporting matrices to deliver cells into infarcted cardiac muscle. Bioactive and biocompatible hydrogels mimicking biochemical and biomechanical microenviro...
متن کاملBiomaterials for Cardiac Tissue Engineering
Cardiovascular diseases (CVD) are a leading death cause in developed countries (1 of every 3 deaths in the United States in 2008) [1]. Changes in diet and habits are causing CVD to become major mortality pathologies in developing countries too [2] (they are already responsible for a 30% of the world deaths). This group of diseases constitutes a great burden for the national health systems, cons...
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ژورنال
عنوان ژورنال: Nature Protocols
سال: 2009
ISSN: 1754-2189,1750-2799
DOI: 10.1038/nprot.2008.183